Oligoasthenoteratozoospermia and infertility in mice deficient for miR-34b/c and miR-449 loci.
Male fertility requires the continuous production of 6.5 Inch high quality motile spermatozoa in abundance.Alterations in all three metrics cause oligoasthenoteratozoospermia, the leading cause of human sub/infertility.Post-mitotic spermatogenesis inclusive of several meiotic stages and spermiogenesis (terminal spermatozoa differentiation) are tran